The Eshelman Institute for Innovation accepts grant proposals via Route 301, our online grants application and management portal. Click here to access Route 301. Please note that a UNC ONYEN is required to access Route 301. 

An overview of the grant proposal submission process and requirements is outlined below.

Before submitting a grant proposal, please review our funding tiers and criteria as well as the instructions below, as changes were recently made.

Please direct all questions to Mieke Lynch at

For instructions on submitting an opportunistic proposal click here.

 Step 1: Project Outline

  • Project Title
  • Area of Submission
  • Type of Proposal (i.e., Discovery, Translational, or Programmatic)
  • Tier (i.e., Discovery Tier 1, 2, or 3, etc.)
  • Project Duration
  • Team: Please list all co-innovators, collaborators, and personnel affiliated with this project.
  • Supervisor:Faculty should list their Division Chair. Staff should list their direct supervisor.
  • Project Description: Please provide a brief description of the grant proposal. Limit to 100 words.

 Step 2: Budget and Resources

The preparation and inclusion of an initial budget is required. You will use this section to build your budget, disclose other sources of funding, and identify any other resources that may be needed to support your project. Your budget must be approved by the Office of Research Administration before you can submit your proposal. To ensure the Office of Research Administration has adequate time to approve the budget, please complete and submit the budget section of your application at least seven business days prior to the proposal submission deadline.

Additional information to be provided in Step 2 includes:

  • Budget Justification: Should address each of the major costs categories and explain the necessity and basis for the proposed cost.
  • Subcontracts: If you are planning to work with collaborators at institutions outside of the University of North Carolina at Chapel Hill, the Institute requires signed documentation. Please see the Route 301 Grant Proposal Submission Instructions for more information.
  • Additional Funding: The Eshelman Institute for Innovation encourages leveraged funding. Use this section to describe existing funding, as well as plans to apply for competitive funding for this grant proposal.
  • Additional Resources: If funded, will the project require additional support or services from the following departments: Educational Technology, Facilities, Finance (Business Operations), Human Resources, Information Technology, Marketing and Communications, or Research Administration.

 Step 3: Proposal and Policies

As you prepare your proposal, please keep in mind that the EII is looking for proposals that are discovery, translational, or programmatic in nature. Additionally, priority for funding may be given to proposals that include meaningful collaborations among a variety of disciplines, departments, schools or institutions. All grant proposals should address the following:

Problem and/or Need:  Describe the problem and/or unmet need that motivates your unique solution and/or idea.

Evidence and Prior Art:  Outline the evidence and prior work in the area by others and/or the evidence or previous studies by the innovator. Enough evidence should be included in the application to demonstrate that the project is feasible and that the innovator is likely to complete the project successfully within the duration of the award.  Please Note: Not applicable to Tier 1 Discovery grant proposals.

Innovative Solution:  Describe the proposed idea and/or solution. How is it different from other ideas and/or solutions? How will it substantially transform science, medicine, health care delivery, education, outcomes or patient health?

Aims and Approach:  State the specific aims and approach for executing your proposed idea and/or solution.

Multidisciplinary Collaboration:  Describe the multidisciplinary nature of this proposal (i.e., collaborations with other divisions, schools, industry partners, etc.

Next Steps: Describe the plan or path for sustaining this work and/or program beyond initial funding through follow-on funding, commercialization, implementation, etc.


Formatting and Length: Upload your proposal summary as a PDF in the space provided. All proposals should abide by the following formatting guidelines:

  • Margins: At least half-inch
  • Font: No smaller than 11-point Times New Roman or its equivalent
  • Spacing: Single or exactly 12-point line spacing
  • Header: Please include your name, project title and funding tier in the header of each page of the proposal.

Review the proposal summary page limits for each funding tier listed below. Please note that for all grant proposals, in addition to the proposal summary, may include up to two pages of pivotal references.

  • Tier 1: two pages
  • Tier 2: five pages
  • Tier 3: five pages
  • Student & Postdoctoral Fellow Proposals: two pages

Additional information to be provided in Step 3 includes:

  • Anticipated Milestones, Results, and Outcomes: Description of the aims, milestones (if applicable) and anticipated results and/or outcomes associated with the work outlined in the grant proposal. Please also outline the anticipated timeline of completion and indicate how you will measure success for each aim and/or milestone. Please note that Translational and Programmatic grant proposals are required to include milestones as a milestone driven approach is critical to the success of these grant proposals.
  • CV, Resume, or BioSketch: Required for all co-innovators and collaborators.
  • Additional Attachments: Letters of support from external collaborators, video to support your grant proposal, etc.
  • Patent & Invention Policy: Review and agree to the UNC Patent & Invention Policy.
  • Compliance: All awarded proposals that involve conflict of interest, human subjects, animal subjects, intellectual property, specified research materials, or educational research must be reviewed and approved in accordance with the University and School’s policies and procedures.
  • Conflict of Interest Disclosure: Review the UNC Conflict of Interest Policy and disclose any conflicts of interest associated with this grant proposal.